Gene Expression Analysis of PBMC in Different BMD Groups
Abstract：Objective To explore gene expression profile of peripheral blood mononuclear cells(PBMC)in different bone mineral density(BMD)groups. Methods We performed R language to analyze the gene expression profile based onGSE7158 dataset from NCBI;DAVID online tools was utilized for gene functional annotation;Medcalc statistical software was used for ROC evaluation. Results 61 genes were dysregulated and most of them were up-regulated in low BMD compared with high BMD group. The differentiate expressed genes involved in 71 GO-BP,4 GO-CC,6 GO-MF terms and 1 KEGG Pathway. CX-CL10,IFI44L,IGKV4-1 were good markers for differential diagnoses between the two groups,and combination examination of CXCL10 &IGKV4-1 was better for ROC evaluation. Conclusion High-throughput dataset and bioinformatics tools is help for genomic analysis under different pathological conditions,which will provide more comprehensive molecular mechanisms for fur-ther osteoporosis study.
Keywords：osteoporosisbone mineral densityexpression profilefunctional annotationreceiver operator characteristic
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 810-813 )