Effect of Pravastatin on Expression of Cbfa1 in Necrosis of Femoral Head Induced by Steroid

Abstract：Objective To investigate the influence of pravastatin on Cbfa1 expression in steroid induced necrosis of femo-ral. Methods 90 healthy adult New Zealand white rabbits were randomly divided into 3 groups:the control group,the experi-mental group and the model group,with 30 rats in each group. In experimental group,model group,models of avascular necrosis of the femoral head were induced. And the experimental group was gavaged with pravastatin,the control group and model group were administrated with distilled water. We observed rabbit's bone tissue and blood vessel number and defect of bone and used fluorescence quantitative PCR method for detection of Cbfa1 expression levels. Results In the experimental group,the number of blood vessels were(8. 4 ± 1. 6),vascular diameter was(9. 8 ± 1. 2)μm,defect of bone lacuna rate was(20. 3 ± 4. 7)% . At8 weeks,12 weeks,16 weekstheinCbfa1 expressionleveloffemoralheadwere( 0 . 531 ± 0 . 074 )、( 0 . 717 ± 0 . 079 )、(0. 885 ± 0. 083). It is higher than the other two groups. Conclusion Pravastatin can promote the expression of Cbfa1 in avascular necrosis of the femoral head,so as to improve the pathological tissues. It is suggested that pravastatin has an impor-tant value in treatment of steroid induced femoral head necrosis.