Association of Methylenetetrahydr of olate Reductase(MTHFR)Polymorphism with Osteoporosis in Mongolian Postmenopausal Women

Abstract：Objective To investigate the relationship between methylenetetrahydrofolate reductase( MTHFR)gene C677T、A1298C polymorphisms and osteoporosis in Mongolian postmenopausal women. Methods One hundred and fifty post-menopausal female patients with osteoporosiswere enrolled. one hundred and forty-five contrasts were healthy Mongolian postm-enopausal women outpatients matched with age to conduct a case-control study. Bone mineral density(BMD)at lumbar spine, femoral neck,trochanter and Ward's triangle were measured by dual-energy X-ray absorptiometry(DEXA). The T value is less than or equal to -2. 5 for the diagnosis of osteoporosis;-2. 5≤T≤ -1. 0 for bone decreased;the T≥ - 1. 0 content of normal bone. and MTHFR gene polymorphism measurement were performed to all subjects. Results The frequencies of MTHFR C677T Genotype CC、CT and TT in osteoprosis group were 29. 3% ,44. 0% and 27. 7% ,respectively,in the contrasts group. The frequen-cies of MTHFR were 42. 8% 、44. 8% and 12. 4% . the difference between groups was statistically significant(P = 0. 017). The frequencies of T allelic genes was 48. 7% in osteoporosis group,evidently higer than that in contrast group(34. 8% ,P =0. 005). T was the risk factor of osteoporosis(OR =1. 77,95% CI =1. 18 ~2. 64,P =0. 001). Comparing to the CC,TT genotype carriers loose osteoporosis risk increases to 3. 15 times(95% CI =1. 45 ~6. 86,P =0. 004). On the otherside,Polymorphism of MTHFR A 1298C on the occurrence of postmenopausal osteoporosis had no significant effect(P =0. 513). The effect was more obvious in 60 years of age or elder and high BMI in women. Conclusion The MTHFR C677T polymorphism may contribute to the suscepti-bility of osteoporosis in Mongolian postmenopausal women.