Effect of Alprostadil Injection On Vascular Crisis Following Microsurgery

Zha Zhuqing; Cheng Chunsheng

Abstract：Objective To investigate the effect of alprostadil injection on vascular crisis following microsurgery. Methods Common carotid artery of rats was cut off and anastomosed using end-to-end vascular anastomosis. Hemostasis and suture were administrated after anastomosis status was determined. Then alprostadil injection,heparin sodium and normal saline were injected with tail vein injection according to the animal grouping,respectively. Thrombogenesis in anastomotic stoma was ob-served and whole high blood viscosity,whole low blood viscosity,whole blood viscosity and erythrocyte mechanical fragility were detected. The inner membrane was observed with scanning electron microscope. Results The thrombus occurrence rate in anastomotic stoma in alprostadil group was significantly lower than that in model group(P < 0. 05),and showed no significant difference compared with heparin sodium group(P > 0. 05). The whole high blood viscosity,whole low blood viscosity,whole blood viscosity and erythrocyte mechanical fragility in alprostadil group was significantly lower than that in model group(P < 0. 05),and lower than that in heparin sodium group but no significant(P > 0. 05). The cellulose coverage,thrombocyte adherence and endothelial cells cytothesis in anastomotic stoma represented no significant difference between alprostadil group and model group. The inhibition of thrombocyte adherence after surgery 30 min and 7 days in alprostadil group and model group were be superior to that in model group. Conclusion Alprostadil injection can reduce the thrombogenesis in anastomotic stoma,blood viscosity and erythrocyte mechanical fragility,and inhibit the conglutination of erythrocytes and thrombocytes. It shows preven-tion and treatment function in vascular crisis after surgery.