Evaluation of Silicate Absorbable Bone Cement in Animals

Zhu Haibo; Ma Nan; Zhong Wuxue

Abstract：Objectiv To observe biocompatibility,biodegradability and osteogenesis characteristic of a new kind of silicate bone cement. Methods Bone defects of 5 mm × 10 mm were made at both femoral condyles of 24 rabbits,and calcium phos-phate cement(CPC)or calcium-phosphate-silicate composite bone cement(CPC-CS)were injected in bone defects of rabbits. We observe the degradation of material in the body and new bone formation through X-ray and HE staining in 4. 8. 12 weeks af-ter operation. Results Without degradation of materials at 4 weeks,the fiber tissues were formed between materials and bones. The CPC-CS materials degradation was more obvious than the CPC materials,the fiber tissues between materials and bones gradually were replaced by new bone tissues,more new bone was found in CPC-CS group at 8 weeks. At 12 weeks,the CPC-CS materials degradation was more obvious than the CPC materials,the CPC group degradation rate was 32. 4% ,CPC-CS group was 45. 4% ,the CPC-CS materials degradation rate was significantly higher than the CPC materials(P < 0. 01). Conclu-sion Calcium-phosphate-silicate composite bone cement has good biocompatibility,mechanical strength,osteogenesis charac-teristic and degradability. Calcium-phosphate-silicate composite bone cement will be a new bioactive bone repair material.