Application of Injectable Calcium Phosphate Cement with rhBMP-2 in the Elder Patients with Proxi-mal Humeral Fractures
Abstract：Objective To evaluate the effect and safety of bone grafting with injectable calcium phosphate cement with rh-BMP-2 in the elderly patients with proximal humeral fractures. Methods Fifty-nine proximal humeral fractures were treated by CPC with rhBMP-2(experimental group)or CPC(control group)with ORIF. The difference between two groups in terms of Lane-Sandhu criterion and the function of the shoulder joint were compared. Results The mean period of follow-up was 14. 2 months. All local incision had no itch sensation or pain. The experimental group average period of osseous healing was 20. 8 weeks,and the control group was 25. 8 weeks. There was obvious significant difference between two groups in terms of Lane-Sandhu criterion. Moreover,the function of the shoulder joint was better. 1 year after operation according to Neer Joint function grading. There was obvious significant difference between the two groups(P < 0. 05). Conclusion Calcium phosphate cement with rhBMP-2 is safe,conveniente,and has less complicationr. The calcium phosphate cement with rhBMP-2 has better support-ing for bone defect area after solidification and increasing the safety of functional motion at the early stage. Meanwhile,rhBMP-2 / CPC can be the suitable bone substitutions for bone defect in fracture of the elder proximal humeral fractures.
Keywords：calcium phosphate cementbone morphogenetic protein-2Bone substitutionsproximal humeral fractures
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 883-886,887 )