Effect of RAGE on Bone Metabolic Disorders in Diabetic Model of Rats
Abstract：Objective To observe the bone metabolic characters in diabetic model of rats and bone expressions of RAGE. Methods Diabetic model of male rats was set up by feeding high-glucose and high-fat diet and injecting intraperitoneally with a low-dose streptozotocin(STZ). All rats were sacrificed after 20 weeks. The biomechanical indexes,glycosylated hemoglobin (GHb)A1c,serum advanced glycation end-products,fasting plasma glucose,fasting serum insulin were measured. Serum AGEs were measured with fluorospectrophotometer. RAGE was measured with RT-PCR. Results Compared with normal control group,the level of GHbA1c、serum AGEs、FPG、FINS of male diabetic model of rats and Goto-kakizaki rats markedly in-creased,and the biomechanical indexes markedly decreased. RAGE was detected by RT-PCR in diabetic male rats and Goto-kakizaki rats. Conclusion Bone mineral density and bone strength decreased,and risk of fracture increased in diabetic male rats and Goto-kakizaki rats. AGEs-RAGE interaction contribute to disturbed bone remodeling.
Keywords：diabetes mellitusratsbone biomechanicsadvanced glycation end-products
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 618-621 )