Effect of Zoledronic Acid on the Healing of Distal Radial Fracture

Abstract：Objective To observe the effect of zoledronic acid on distal radius fractures in elderly patients after operation. Methods Analysis of 136 cases of distal radius fractures underwent operation in our hospital from January 1,2012 to Decem-ber 31,2012,118 patients were followed up(87% ),Patients were divided into zoledronic acid group(group A,59 patients) and control group(group B,59 patients),group A with an average age of 73. 09 ± 5. 04,12 male patients,47 female patients, postoperative second to seventh day with anti osteoporosis treatment of zoledronic acid,and a conventional calcium and calcitri-ol supplement,B group with an average age of 73. 25 ± 6. 96,male 14 patients,female patient 45,postoperative second to sev-enth day with anti osteoporosis treatment of Injection of Miacalcic,continue using of Miacalcic nasal spray from discharge to postoperative 3 months,and a conventional calcium and calcitriol supplement,4 week and 3 month follow-up of fractures heal-ing and postoperative 1 year follow-up of bone mineral density. Results The fracture healing in elderly patients with no obvi-ous effect of zoledronic acid anti osteoporosis medicine after distal radius fracture,callus in A group is more than callus in group B,postoperative bone mineral density increased over one year ago. Conclusion The effect of osteoporosis treatment with zoledronic acid medicine in elderly patients with distal radius fractures is significant,while no obvious negative effect on the healing of the osteoporotic distal radius fracture.