Two Cyclooxygenase Inhibitors in Cervical Open Door Laminoplasty Comparison Research

YANG Deng-feng; WANG Jian; WANG Sheng-hai

Abstract：Objective To evaluate the pain relief effect of parecoxib sodium(selective cyclooxygenase-2 inhibitor)versus flurbiprofen axetil(non-selective cyclooxygenase inhibitor)used after open door laminoplasty in early short-term fuctional re-covery. Methods This is a prospective,randomized,double-blind,parallel and controlled study. According to inclusion/ exclu-sion criteria,60 patients undergoing open door laminoplasty were randomly assigned to one of the 2 groups from March,2010 to March,2013. All the operations were performed by the same group of surgeons under general anesthesia. Before the open door laminoplasty operation incision“cocktail anagesia injection”was given to every patient,which contained 150 mg ropivacaine, 0. 5 mL epinephrine(1 : 1 000). The parecoxib sodium group received parecoxib sodium(40 mg,every 12 hours)after six hours of surgery,while the flurbiprofen axetil group received flurbiprofen axetil(100 mg,every 12 hours)after six hours of sur-gery,the pain score(visual analog scale,VAS)at rest and during activity,active range of motion of the cervical from the first to the seventh postoperative day,active range of motion of the cervical on postoperative day 30,the dose of tramadol hydrochloride and pethidine hydrochloride used postoperatively and adverse reaction happened postoperatively. Results There were no sig-nificant differences in such outcome measures as VAS scores at rest and during activity,active range of motion of the cervical from the first to the seventh postoperative day,active range of motion of the cervical on postoperative day 30,the dose of tram-adol hydrochloride and pethidine hydrochloride used postoperatively and adverse reaction. Conclusion Preoperative analgesia by using selective cyclooxygenase-2 inhibitor and non-selective cyclooxygenase inhibitor are effective for postoperative pain management after open door laminoplasty. This study has not revealed that there is better pain relief effect of parecoxib sodium than flurbiprofen axetil after open door laminoplasty in early short-term fuctional recovery.