Effect of remazolam combined with ropivacaine in intraspinal anesthesia for elderly patients with lower extremity fractures

HU Yafang; LI Shimei; JIAN Zhonglu

doi:10.3969/j.issn.1671-8631.2025.10.007

Abstract：Objective:To evaluate the efficacy and safety of remazolam combined with ropivacaine in intraspinal an-esthesia for elderly patients undergoing lower extremity fracture surgery.Methods:A total of 80 elderly patients sched-uled for intraspinal anesthesia for lower limb fracture surgery were randomly divided into two groups using a random number table:the control group(n=40)received intraspinal anesthesia with propofol and ropivacaine,while the study group(n=40)received intraspinal anesthesia with remazolam and ropivacaine.The anesthetic effect,respiratory and circulatory parameters,and incidence of adverse reactions were compared between the two groups.Results:The propor-tion of patients with vigilance/sedation observation(OAA/S)score ≥3 was significantly higher in the study group than in the control group(P＜0.05).The observation time and extubation time in the post-anesthesia care unit were shorter in the study group compared to the control group(P＜0.05).Respiratory rate(RR)and oxygen saturation(SpO2)decreased significantly at t2 but gradually increased at t3-t5;There was no significant difference in RR and SpO2 levels between the two groups at t1-t5(P＞0.05).There was no significant difference in the levels of mean arte-rial pressure(MAP)and heart rate(HR)between the two groups at t1(P＞0.05).They all decreased significantly at t2,increased at t3,and then decreased gradually.The levels of MAP and HR in the observation group were better than those in the control group at t2-t5(P＜0.05).The incidence of adverse reactions was significantly lower in the study group than in the control group(P＜0.05).Conclusion:Intraspinal anesthesia with remazolam combined with ropiva-caine provides superior anesthetic effects,faster recovery,shorter extubation times,stable hemodynamic parameters,and fewer anesthetic-related adverse reactions in elderly patients with lower extremity fractures.