Clinical study on the correlation between FOXM1,CDK8,MALAT1 gene polymorphism and bronchop-ulmonary dysplasia in extremely preterm infants

WANG Zhansheng; WANG Pin; SHI Xueying; MI Nan; LI Xin; JIAO Yang; LIU Yulu

Abstract：Objective:To analyze the correlation between forkhead box protein M1(FOXM1),cyclin-dependent kinase 8(CDK8),and lung adenocarcinoma metastasis-related transcript 1(MALAT1)with bronchopulmonary dys-plasia(BPD)in extremely preterm infants(VPI).Methods:A total of 80 VPI cases treated in the hospital from Decem-ber 2021 to December 2023 were selected and followed up for 28 days to count the incidence of BPD.The VPI with BPD were included in the BPD group,and those without BPD were included in the non-BPD group.The polymorphism dis-tribution frequency of FOXM1 gene single nucleotide polymorphism(SNP)loci rs3829865 and rs7294943,CDK8 gene rs17083838 and rs7992670 loci,and MALAT1 gene rs4102217 and rs619586 loci in the two groups were tested by Har-dy-Weinberg balance test.The genotypic polymorphism of the above loci was compared between the two groups.Lo-gistic regression model was used to analyze the influencing factors of BPD in VPI.Results:There were no significant differences in the actual gene frequency and the theoretical genotypic frequency predicted by Hardy-Weinberg genetic balance law between BPD group and non-BPD group(P＞0.05).Compared with non-BPD group,BPD group had higher AA genotype frequency and A allele frequency at FOXM1 gene rs7294943 locus,AA genotype frequency and A allele frequency at CDK8 gene rs17083838 locus,and CG genotype frequency at MALAT1 gene rs4102217 locus(P＜0.05).Logistic regression model analysis showed that gestational age at birth,invasive mechanical ventilation time,AA genotype at FOXM1 gene rs7294943 locus,AA genotype at CDK8 gene rs17083838 locus,and CG genotype at MAL-AT1 gene rs4102217 locus were influencing factors of BPD in VPI(P＜0.05).Conclusion:The AA genotype at FOXM1 gene rs7294943 locus,AA genotype at CDK8 gene rs17083838 locus,and CG genotype at MALAT1 gene rs4102217 locus may be related to the occurrence of BPD in VPI.