Effect of intravenous infusion of dexmedetomidine combined with local infiltration anesthesia on percu-taneous kyphoplasty in middle—aged and elderly people and the influence of stress response
LI Yongli
ZHAO Lin
Abstract：Objective:To investigate the anesthetic effect and stress response of dexmedetomidine hydrochloride combined with local infiltration anesthesia in middle—aged and elderly patients undergoing Percutaneous kyphoplasty(PKP).Methods:According to the random number table method,82 middle—aged and elderly PKP patients who came to the Xi'an Hospital of General Global China Railway for treatment from February 2022 to December 2023 were divided into control group(41 cases)and observation group(41 cases).The control group was given local infiltration anesthe-sia,and the observation group was given dexmedetomidine hydrochloride combined with local infiltration anesthesia.The vital signs,alertness/sedation score(OAA/S),stress response and adverse reactions of the two groups were com-pared before medication(t0),10 min after medication(ta),at the time of bone cement injection(tb),at the end of sur-gery(tc)and 1 hour after surgery(td).Results:The OAA/s scores of ta,tb and tc in the observation group were lower than those in the control(P＜0.05).The average arterial blood pressure and heart rate in the observation group were lower than those in the control group at ta,tb,tc and td(P＜0.05).Norepinephrine,blood sugar,plasma cortisol and epi-nephrine in the observation group were lower than those in the control group,(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups,the difference was statistically significant(P＞0.05).Conclusion:Dexmedetomidine hydrochloride combined with local infiltration anesthesia can improve the hemody-namics of middle—aged and elderly patients with PKP,reduce stress response and improve anesthesia effect,with high safety.
Keywords：dexmedetomidine hydrochloridelocal infiltration anesthesiapercutaneous kyphoplastyanesthesia effectstress response
Publication Date：2025-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 247-250 )