Glucose and lipid metabolism in obese children and its correlation with with precocious puberty

TONG Xiaolong

Abstract：Objective:To investigate the status of glucose and lipid metabolism in obese children and analyze the effect of glucose and lipid metabolism on precocious puberty in children.Methods:All 65 obese children(obesity group)and 65 normal weight children(control group)who met the inclusion criteria from March 2018 to March 2021 were se-lected.The indexes related to glucose and lipid metabolism were detected in the two groups.According to Tanner's stag-ing standard,the precocious puberty of two groups of children was evaluated,and the influence of glucose and lipid me-tabolism on precocious puberty of obese children was analyzed.Results:The indexes of blood glucose metabolism in o-besity group were higher than those in control group(P＜0.05).The triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL)and uric acid(UA)in obesity group were higher than those in control group,while high den-sity lipoprotein(HDL)was lower than that in control group(P＜0.05).The Tanner scores of boys and girls in obesity group were higher than those in control group,and the incidence of precocious puberty was higher than that in control group(P＜0.05).By Spearman correlation coefficient test,the results showed that the Tanner scores of testis and pu-bic hair in boys and breast and pubic hair in girls were positively correlated with fasting blood glucose(FPG),2 h post-prandial blood glucose(2 h PG),glycosylated hemoglobin(HbAlc),fasting insulin(FINS),insulin resistance index(HOMA-IR),TG,TC,LDL and UA(P＜0.05),and negatively correlated with HDL(P＜0.05).By Logistic regres-sion analysis,the results showed that the elevated levels of FPG,GHB,fins,HOMA-IR,TG,TC and UA were the risk factors of precocious puberty in obese children(OR＞1,P＜0.05).Conclusion:Obesity is associated with precocious puberty,and the disorder of glucose and lipid metabolism is an important factor to promote precocious puberty in obese children.