Efficacy of periprostatic fat thickness combined with two-parameter MRI in diagnosis of prostate cancer and its correlation with the efficacy of docetaxel

HAO Xiaoming; WANG Yujie

Abstract：Objective:To investigate the efficacy of periprostatic fat thickness(PPFT)based on magnetic resonance imaging(MRI)in assisting biparametric MRI(Bp-MRI)in the diagnosis of prostate cancer and its value of chemo-therapy effect of docetaxel.Methods:The clinical data of patients with the indication of prostate biopsy who underwent prostate biopsy in hospital from June 2021 to March 2024 were collected,including PPFT measured by MRI,PI-RADSV2.1 score,pathological GleasonScore(GS)and clinical data of docetaxel before and after chemotherapy after prostate biopsy or radical prostatectomy.From June 2021 to March 2024,the clinical data of 232 patients with prostate biopsy were selected and divided into prostate cancer group(n=64)and prostate hyperplasia group(n=168)according to the pathological results.Single factor and multivariate Logistic regression were used to screen the difference indexes between the two groups.The diagnostic performance of PPFT with Bp-MRI was analyzed andthe ROC curve was drawn.Pearson correlation analysis was used to describe the correlation between PPFT and prostate cancer risk classifi-cation.Results:Multivariate Logistic regression screened out PI-RADS and PPFT.The area under the curve(AUC)of PI-RADS and PPFT in the diagnosis of prostate cancer was respectively 0.841 and 0.679,the sensitivity was 88％and 59％,the specificity was 62％and 72％(P＜0.05).The AUC of PI-RADS combined with PPFT in the diagnosis of prostate cancer was 0.873,the sensitivity was 69％,and the specificity was 92％(P＜0.05).Pearson correlation a-nalysis showed that decrease of PPFT was positively correlated with the decrease of PSA after docetaxel chemotherapy(P=0.003)and high-grade prostate cancer(GS≥8)(P=0.015).There was no correlation between PPFT and body mass index(BMI)and prostate volume(PV).Conclusion:Periprostatic fat thicknessmeasured by MRI can not only im-prove the diagnostic efficiency of prostate cancer for biparametric MRI,but also have weak positive correlation with the sensitivity of docetaxel chemotherapy.