Application of 256 slice CT perfusion imaging combined with galactose agglutinin 3 in preoperative di-agnosis of mediastinal lymph node metastasis in lung cancer

ZHANG Yan; JING Limin; WANG Wei; LI Dong

Abstract：Objective:To analyze the application value of 256 slice CT perfusion imaging parameters(CTPI)com-bined with galactose agglutinin 3(Gal-3)in preoperative diagnosis of mediastinal lymph node metastasis in lung canc-er.Methods:A retrospective analysis was conducted on the clinical data of 87 lung cancer patients admitted to hospital from April 2022 to April 2023.They were divided into metastatic group(n=45)and non metastatic group(n=42)based on the status of mediastinal lymph node metastasis.We also selected healthy individuals who underwent physical examinations in hospital from April 2022 to April 2023 as the control group(n=40).All subjects were tested for serum Gal-3 levels and CT perfusion scanning was performed using Brilliance iCT scanner.Compare three groups of CTPI[surface permeability(PS),perfusion value(PV),pulmonary artery blood flow(PAF),blood volume(BV),mean tran-sit time(MTT),peak enhancement(PEI),bronchial artery blood flow(BAF)],and serum Gal-3 levels.Evaluate the diagnostic efficacy of CTPI,serum Gal-3 levels,and combined detection in preoperative mediastinal lymph node metas-tasis of lung cancer using receiver operating characteristic(ROC)curves.Results:The PS,PV and Gal-3 in the meta-static group were significantly higher than those in the non-metastatic group and the control group,while the PS,PV and Gal-3 of the non metastatic group were higher than those of the control group(P＜0.05).ROC curve analysis shows that the area under the line of PS,PV and Gal-3 was higher than that of each other,there was significient difference(P＜0.05).Conclusion:The combination of 256 layer CTPI and serum Gal-3 levels has high diagnostic value for preoperative mediastinal lymph node metastasis in lung cancer patients,and can provide important basis for preoper-ative evaluation of lung cancer patients.