Study on the preparation process and quality standard of guiqi nourishing blood and relieving itching granule dosage
ZHAN Aihua
FANG Lijun
TU Yuanzhen
WANG Fang
CHA Jianrong
YAO Huirong
Abstract：Objective:To study the preparation process and quality standard of guiqi nourishing blood and relieving itching granules.Methods:Particle size,moisture,solubility,loading difference and microbial limit of granules were ex-amined relevantly.L9(33)orthogonal test was used to examine the amount of water added,extraction time and number of extractions to determine the levels of factors,and the content of rhodopsin was used as an index to optimize the prep-aration process.The identification of rhodopsin and astragaloside in granules was carried out by thin-layer chromatog-raphy,and the content of rhodopsin in granules was determined by high performance liquid chromatography.Results:The molding rate of radix astragali nourishing blood and relieving itching granules was 97.13％,and the relevant exami-nations of the granules complied with the regulations.The preferred optimal preparation process was 8 times of water,extraction time of 2 h,and 2 times of extraction,and the results of thin layer chromatography(TLC)showed clear spots with high specificity,and the results of high performance liquid chromatography(HPLC)showed that the average con-tent of rhodopsin was 0.0156 mg/g,and the average recoveries were 98.28％with RSD of 0.35％.Conclusion:The op-timized preparation process was stable and the method was simple and accurate.The method is simple and accurate,and the established quality standard is exclusive and reproducible,which can be used for the quality control of guiqi nouris-hing blood and relieving itching granules.
Keywords：radix astragali nourishing blood relieving itching granulespreparationquality standardthin layer chromatographyhigh performance liquid chromatography
Publication Date：2024-09-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 686-691 )