Study on the mechanism of shenzhu san in treating gastrointestinal motility disorder by network phar-macology
WU Lisan
LI Xiaoyu
LI Linjie
ZHANG Huanhu
Abstract：Objective:Based on network pharmacology and molecular docking,the mechanism of shenzhu san in treating gastrointestinal motility disorder(GMD)was studied,which provided reference for clinical application and ex-periment.Methods:Get the interaction between the targets,and use software for topology analysis to find the core tar-get.Enrich and analyze the target and verify the molecular docking.Results:There are 114 kinds of active ingredients in shenzhu san,and 253 active targets.There are 119 targets at the intersection of shenzhu san and GMD.The results of enrichment analysis show that the related targets are significantly enriched in various biological processes and cell func-tions,and the targets are closely related to GMD signaling pathway.The intersecting targets are mainly distributed in thyroid,prostate,pineal gland,heart,pituitary gland,liver and prefrontal cortex.Conclusion:The main effective compo-nents of shenzhu san may interfere with GMD through multiple targets and signal pathways.
Keywords：gastrointestinal motility disordershenzhusannetworkpharmacologymolecular docking
Publication Date：2024-09-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 655-660 )