Effect of jiangphosphorusyishen powder on hyperphosphatemia inmaintenance hemodialysis patients in-fluence of nutritional status

HAN Jie; WANG Ying

Abstract：Objective:To study the effects of jiangphosphorusyishensan on hyperphosphatemia and nutritional sta-tus in maintenance hemodialysis patients(MHD).Methods:From January 5,2022 to July 5,2023,80 eligible MHD pa-tients were admitted and divided into control group and treatment group according to random number table method,with 40 casesin each group.The control group was treated with calcium carbonate combined with low calcium dialysate,while the treatment group was treated with jiangphosphorusyishen powder combined with low calcium dialysate.The two items of electrolytes(blood phosphorus,blood calcium),renal function serum creatinine(Scr)and serum urea ni-trogen(BUN)in renal function,parathyroid hormone(iPTH)and nutrition index(hemoglobin,serum albumin and ser-um prealbumin)in the two groups were observed and recorded before and after treatment,and the relevant scores of traditional Chinese medicine(TCM)syndromes in the observation group and the treatment group were recorded.The safety and therapeutic effect of the two groups were evaluated.Results:After the end of the experiment,the total effec-tive rate of the control group was 80.00％,and that of the treatment group was 92.50％,which was significantly higher than that of the control group,and the difference was statistically significant(P??0.05).After treatment,the TCM syndrome scores and total scores of the control group were significantly higher than those of the treatment group(P＜0.05).Electrolytes,renal function and iPTH in control group were significantly higher than those in treatment group,with statistical significance(P＜0.05).There was no statistical significance between the treatment group and the ob-servation group(P＞0.05).Conclusion:In the treatment of hyperphosphatemia in maintenance hemodialysispatients,Chinese herbal preparation jiang phosphorus yishen powder combined with low calcium dialysate has obvious curative effect compared with the conventional treatment of calcium carbonate combined with low calcium dialysate,but the effect on nutritional status is not so good.jiangphosphineyishen powder can improve the level of calcium and phosphor-us in the body of patients,supplement calcium and suppress phosphorus,and the effective mechanism of jiangphosphin-eyishen powder may be related to reducing iPTH secretion in the body of patients,improving renal microcirculation and reducing renal fibrosis.