Analysis of 277 cases of adverse reactions of piracetam oral preparation

GUO Huiqing; HUANG Jing

Abstract：Objective:To analyze the characteristics and patterns of adverse drug reactions(ADR)in piracetam oral preparations,and provide reference for improving the rationality and safety of clinical medication.Method:A retrospec-tive statistical analysis was conducted on 277 ADR reports of piracetam oral preparation from January 1,2004 to Au-gust 31,2021 in Hebei Province.Results:All 277 ADR reports of piracetam oral preparation were reported,with a male to female ratio of 2.15∶1.The proportion of middle-aged and elderly patients aged 45 and above was the highest.Ad-verse reactions affecting systems/organs mainly include gastrointestinal system damage,neurological damage,mental disorders,skin and skin accessory damage.The main causes of medication are cerebrovascular disease,memory loss,cer-ebral infarction,and intracranial injury.ADR mainly occurs within 3 days of starting medication,with the highest pro-portion occurring on the day of medication(41.16％).After the occurrence of ADR,the main intervention measures were discontinuation of medication.51.62％of patients recovered after discontinuation,and 33.21％of patients im-proved.Conclusion:Continue to pay attention to gender differences in the occurrence of ADR in patients using oral pi-racetam preparations;strengthen medication monitoring for middle-aged and elderly patients.Within 3 days of medica-tion,it is a high incidence period for ADR in piracetam oral preparations.Once ADR occurs,it is recommended to stop the medication and seek medical treatment if necessary.Holders of drug marketing licenses actively improve drug in-structions to better guide clinical safe.