The serum expression levels of IL-17 and IL-22 in syphilis patients before and after treatment and their clinical significance
LI Penghua
ZHAO Shuqiang
Abstract：Objective:To investigate the expression levels and clinical significance of interleukin(IL)-17 and IL-22 in the serum of syphilis patients before and after treatment and in healthy individuals.Methods:Flow cytometry was used to detect the expression levels of IL-17 and IL-22 in the serum of syphilis patients,treated syphilis patients and healthy individuals.Results:The serum expression level of IL-22 in the healthy group was lower than that in the syph-ilis group(P＜0.05).However,the expression level of IL-17 in serum was not statistically significant in the above three groups.The results of ROC curve showed that the AUC value of IL-22 in serum for predicting syphilis was 0.848(P＜0.05),which confirmed that IL-22 had high diagnostic value.The AUC value of IL-17 was not statistically significant.Conclusion:IL17 and IL-22 are important cytokines in the immune mechanism of syphilis,and IL-22 has important clinical value in the diagnosis and treatment of syphilis.
Keywords：syphilistreponema palliduminterleukin-17interleukin-22cytokines
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 589-591 )