Clinical efficacy and safety of danzhi xiaoyao tablet combined with metronidazole vaginal gel in the treatment of bacterial vaginosis

WU Weigang; SHEN Ningning; LIU Lanlan; ZHANG Jingyi; LAI Shanghai

Abstract：Objective:To explore the specific effect of danzhi xiaoyao tablet combined with metronidazole vaginal gel in the treatment of bacterial vaginosis(BV).Methods:All 152 BV patients admitted to hospital from July 2021 to April 2023 were selected and randomly divided into two groups,with 76 patients in each group.The control group was treated with metronidazole vaginal gel,and the study group was treated with danzhi xiaoyao tablets while using metronidazole vaginal gel.Both groups were treated continuously for 7 days and followed up for 3 months.The traditional chinese medicine syndrome points,clinical efficacy(recovery,effectiveness,and ineffectiveness),levels of inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)],the incidence and recur-rence rate of vaginal microbiota(Nugent score),adverse reactions(itching,burning sensation,skin irritation,loss of ap-petite,dry mouth,etc.)were compared between two groups.Results:After treatment,the total effective rate of the ob-servation group was higher than that of the control group(P＜0.05),and the TCM syndrome score and the scores of IL-6,IL-8,TNF-αand Nugent in the observation group were lower than those before treatment and those in obser-vation group were lower than those in the control group,there was significient difference(P＜0.05).There was no sig-nificant difference in the incidence of adverse reactions between the two groups(P＞0.05).The recurrence rate of the observation group was lower than that of the control group at the first month,the second month and the third month af-ter treatment(P＜0.05).Conclusion:Danzhi xiaoyao tablet combined with metronidazole vaginal gel in the treatment of BV can effectively improve vaginal microecology,reduce the level of inflammatory factors,enhance clinical efficacy,reduce disease recurrence,and have high drug safety.