Analysis of influencing factors and intervention measures of cancer-related fatigue in patients under-going radical thyroidectomy

SHI Min; LI Jing; XU Guiyu

Abstract：Objective:To explore the influencing factors of cancer-related fatigue(CRF)in patients undergoing radical thyroidectomy,formulate the related intervention measures,and analyze the intervention effect.Methods:All 82 patients with thyroid cancer from March 2020 to February 2023 were selected as the study subject(control group)and were divided into CRF group and non-CRF group according to the occurrence of CRF.The risk factors affecting post-operative CRF were analyzed,and targeted intervention measures were developed according to the risk factors.50 pa-tients undergoing radical thyroidectomy from February 2023 to October 2023(intervention group)were intervened to analyze the effect of this measure on the occurrence of CRF in patients.Results:The proportion of people with anemia,postoperative thyroid-stimulating hormone(TSH)level≥0.5 mU/L,depression,anxiety and sleep disorder in CRF group were higher than those in non-CRF group while the proportion of people with postoperative radioiodine therapy was lower than that in non-CRF group(P＜0.05).Anemia,postoperative TSH level≥0.5 mU/L,depression,anxiety and sleep disorder were the risk factors for postoperative CRF in patients undergoing radical thyroidectomy,and postop-erative radioiodine therapy was the protective factor(P＜0.05).Cancer fatigue scale of physical fatigue,emotional fa-tigue and total scores in intervention group were lower than those in control group.The scores of Self-rating anxiety scale(SAS),self-ratingdepression scale(SDS)and pittsburgh sleep quality index(PSQI)in the intervention group were lower than those in the control group.Conclusion:Anemia,reduced postoperative TSH inhibition,depression,anxi-ety and sleep disorder are the influencing factors for postoperative CRF in patients with radical thyroidectomy.Accord-ing to the related intervention measures for various risk factors,the analysis finds that the intervention measure can re-lieve the CRF degree and improve the anxiety,depression and sleep disorder of patients.