Observation on the clinical effect of baihu decoction combined with xuebijing injection in the treatment of sepsis(syndrome of toxic heat and internal excess)

JIANG Yi; HU Haiqiang; GU Wen

Abstract：Objective:To investigate the clinical efficacy of baihu decoction combined with xuebijing injection in the treatment of sepsis(syndrome of toxic heat and internal excess).Methods:All 80 patients with sepsis admitted from June 2020 to December 2022 were divided into control group(40 cases)and observation group(40 cases)by random number table method.The control group was treated with conventional treatment,and the observation group was trea-ted with baihu decoction combined with xuebijing injection.The efficacy of both groups was evaluated after 7 days of treatment.The clinical efficacy,coagulation function,platelet count,lactic acid level,TCM syndrome score,body temper-ature,disease severity,ICU stay and adverse reactions were compared between the two groups.Results:The total effec-tive rate of the observation group was higher than that of the control group.Prothrombin time(PT),D-dimer(DD),fibrinogen(FIB),partial prothrombin time(APTT),lactic acid level,TCM syndrome score,body temperature,acute physiology and chronic health score(APACHEⅡ),and infection-related organ failure estimate(SOFA)score were lower than those of control group.The platelet count was higher than that of control group(P＜0.05).The platelet count of the two groups after treatment was higher than that before treatment,and the observation group was higher than the control group,the difference was statistically significant(P＜0.05).Conclusion:Baihu decoction combined with xuebijing injection is safe and effective in the treatment of sepsis(syndrome of toxic heat and internal excess).Combining TCM holistic syndrome differentiation with modern western medicine provides a new way for the prognosis of sepsis.