Biochemical study of nosenazone sodium in the treatment of spinal muscular atrophy

PAN Zhangying; HUANG Jinrong; LI Wenzhong; LIU Huaping

Abstract：Objective:To explore the effect of sodium nosinasone on biochemical indicators in the treatment of spinal muscular atrophy(SMA).Methods:A total of 40 SMA patients admitted to hospital from June 2021 to June 2023 were selected,and all SMA patients received treatment with nosenazone sodium.The changes of liver function[alanine amin-otransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT)],renal function[urea(BUN),creatinine(CREA),cystatin C(CysC)],creatine kinase(CK),cerebrospinal fluid[glucose(Glu),Lactate dehydrogen-ase acid(LDH),cerebrospinal fluid protein(TPC)]were compared before and after treatment.Results:Compared with before treatment,the liver function indicators(ALT,AST,GGT)of the patient showed a significant increase on the 14th day of treatment,but showed a downward trend on the 28th day of treatment.The liver function indicators were close to the baseline level on the 63rd day,and the difference was statistically significant(P＜0.05).During the treat-ment period,there was no significant change in the renal function indicators(BUN,CREA,CysC)of the patient,and there was no statistically significant difference in various indicators compared at different time points(P＞0.05).Dur-ing the treatment period,there was no significant change in cerebrospinal fluid indicators(GLU,LDH,TPC),and there was no statistically significant difference when comparing various indicators at different time points(P＞0.05).Com-pared with before treatment,the CK of the patients decreased significantly after treatment,with a statistically signifi-cant difference(P＜0.05).Conclusion:The treatment of SMA patients with NSS sodium is effective and beneficial for reducing their CK levels.It may have a temporary impact on their liver function.However,as the number of treatments increases,liver function indicators gradually return to normal,and there is no significant impact on the patient's kidney function,cerebrospinal fluid,and other indicators.