Study on the mechanism of miR-451a in the treatment of radiation induced mucosal damage in naso-pharyngeal cancer with ginseng yangrong tang
LU Zhibing
LI Ruijuan
WU Zhiqing
XIAO Yongjuan
Abstract：Objective:To observe the therapeutic effect of ginseng yangrong tang on radiation induced mucosal dam-age in nasopharyngeal carcinoma,and to infer the mechanism of action by detecting the expression of micro RNA-451a(miR-451a)and secreted protein acidic and rich in cysteine(SPARC)mRNA.Methods:Thirty patients with radiation-induced oral mucosa injury of nasopharyngeal carcinoma were selected from March 2022 to May 2022 as the observa-tion group and 30 healthy 2023 were selected as the control group.The treatment group was treated with modified she-nyangrong decoction based on syndrome differentiation,and the traditional chinese medicine symptom integral scale,the degree of xerostomia,the degree of oropharyngeal pain and the degree of mucosa injury were compared before and after treatment.The levels of Mir-451a and SPARCmRNA were measured before and after treatment.Results:Ginseng yan-grong Tang can effectively reduce the severity of the main and secondary symptoms,the degree of oral mucosa injury of grade Ⅲ and Ⅳ,the degree of oropharyngeal pain and the degree of xerostomia,and decrease the expression of miR-451a in the serum of the patients,sPARC mRNA translation was enhanced(P＜0.05).There was a positive correlation between MIR-451 a and TCM symptom scores before and after treatment(P＜0.05).Conclusion:Ginseng yangrong tang has a certain clinical therapeutic effect on radiation induced mucosal damage in nasopharyngeal carcinoma.Ginseng yangrong tang can reduce the expression level of miR-451a and increase the expression level of SPARC mRNA,while miR-451a inhibits the translation of SPARC mRNA,providing a theoretical basis for future integrated chinese and western medicine treatment.
Keywords：micro RNA-451aginseng yangrong tangradiation induced mucosal damage in nasopharyngeal carci-nomasecreted protein acidic and rich in cysteinemechanism research
Publication Date：2024-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 243-247 )