Effect of magnesium sulfate combined with ropivacaine iliac fascia block on tourniquet reaction in total knee replacement surger

PANG Wenguang; LIU Li

Abstract：Objective:To analyze the effect of magnesium sulfate combined with ropivacaine iliac fascia block on tourniquet reaction during total knee replacement(TKA).Methods:A total of 90 TKA patients treated in our hospital from May 2020 to May 2023 were selected for this study,and divided into 2 groups with 45 cases each according to dif-ferent anesthesia methods.The control group was given ropivacaine iliac fascial block,and the observation group was given magnesium sulfate intravenous infusion on the basis of the comparison group.Heart rate(HR),mean arterial pressure(MAP),inflammatory stress index,cumulative dosage of ropivacaine,number of analgesic pump compressions and total incidence of adverse reactions were compared between the two groups at different time points.Results:t1 HR and MAP in observation group were compared with those in comparison group,there was significient difference(P＞0.05).HR and MAP of 30 min after aeration(t2),60 min after aeration(t3),90 min after aeration(t4),when tourniquet was loosened(t5)and after extubation(t6)in observation group were lower than those in comparison group(P＜0.05).The level of serum superoxide dismutase(SOD)in the observation group was higher than that in the control group 24 h af-ter surgery,and the levels of serum malondialdehyde(MDA),interleukin-6(IL-6)and C-reactive protein(CRP)in the observation group 24h after surgery were lower than those in the control group(P＜0.05).The cumulative dosage of rop-ivacaine and The Times of analgesic pump in observation group were lower than those in control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Con-clusion:Magnesium sulfate combined with ropivacaine iliac fascia block can effectively maintain hemodynamic stability in patients with TKA during operation,alleviate tourniquet reaction,inhibit inflammation and oxidative factor release,and do not cause serious adverse reactions,so it has certain safety.