The effect of programmed death ligand-1 receptor function in bladder cancer cells on tumor

JIANG Yi; YE Tao; CHEN Zhou; GAO Jiasheng; ZHANG Wensheng

Abstract：Objective:To explore the effect of programmed death receptor-1(PD-1)receptor function on bladder cancer cells.Methods:Eighty patients diagnosed with bladder cancer from October 2020 to October 2022 were selected.The expression of PD-1 in the cancer tissues of patients with bladder cancer and the adjacent bladder tissues 3 cm from the tumor margin were observed by immunohistochemical staining.The expression of PD-1 mrna in cancer tis-sues of patients with bladder cancer and adjacent bladder tissues 3 cm away from the tumor margin was observed and analyzed using reverse transcription polymerase chain reaction.The correlation between the expression level and clinico-pathological parameters(age,gender,clinical stage,pathological grade,etc.)was analyzed.Results:The positive ex-pression rate of PD-1 was 63.75％(51/80).The positive expression rate of PD-1 mRNA was 68.75％(55/80).No significant PD-1 and PD-1 mRNA expression was found in the adjacent tissues of bladder cancer 3 cm from the tumor margin.Clinical correlation analysis showed that the expression of PD-1 was closely correlated with the clinical TNM stage of bladder cancer(P＜0.05),but its expression was not significantly correlated with the age,gender and pathological grade of bladder cancer patients(P＜0.05).Conclusion:PD-1 is highly expressed in cancer tissues of pa-tients with bladder cancer,which plays a certain role in the occurrence and development of bladder cancer tumors and can be used to evaluate the progression of bladder cancer.