Regulating effect of 1,25-dihydroxyvitamin D3 on expression of IL-17 in rats with renal interstitial fbrosis
WANG Qian
LUO Jing
GUO Hui
Abstract：Objective:To investigate the regulating effect of 1,25-dihydroxyvitamin D3[1,25(OH)2D3] on the expression of interleukin-17(IL-17) in rats with renal interstitial fbrosis.Methods:A total of 54 male Wistar rats were randomly assigned to Sham operation,model group and 1,25(OH)2D3 treatment group,in the latter two of which the left urethral ligatoion was performed.In addition,rats in treatment group received 1,25(OH)2D3 intragastric feeding(3 ng·100 g-1· d-1).The rats were sacri ficed at days 1,3 and 7 for extraction of the left kidney.Immunohistochemistry was used to determine the expression of IL-17 and α-SMA in renal tissue of rats.Results:The model group yielded marked expression of α-SMA and IL-17 compared with Shan group(all P<0.01);In 1,25(OH)2D3 treatment group,the expression of α-SMA and IL-17 was suppressed when compared with that of model group(both P<0.01),the differences were statistically significant.Conclusion:IL-17 may participate in the occurrence and development of renal interstitial fbrosis;1,25(OH)2D3 may play a role in immune regulation by down-regulating the expression of IL-17 directly or indirectly.
Keywords：125-dihydroxyvitamin D3renal interstitial fbrosisinterleukin-17
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 289-292 )