Clinical study of sequential oral esomeprazole treatment of endoscopic submucosal dissection postop-erative complications

LIU Xue

Abstract：Objective:To investigate the clinical efficacy of sequential oral esomeprazole in the treatment of postoperative complications of endoscopic submucosal dissection( ESD). Methods:Sixty patients with ESD in hospital from June 2015 to June 2016 were included in the study and randomly divided into the treatment group. The control group of 30 patients using in-travenous omeprazole 40 mg,2 times one day,7 days later renamed Omeprazole Enteric-coated Tablets 40 mg to oral 7 days. The observation group of 30 patients with esomeprazole 40 mg intravenous drip,2 times one days,7 days changed after esome-prazole enteric coated tablet 40 mg to oral 7 days. The postoperative 7 days and 14 days abdominal pain,abdominal distension, belching,nausea and vomiting and other symptoms score improvement;comparison of patients with gastrointestinal bleeding, wound healing and adverse drug reactions. Results:the postoperative patients with abdominal pain,abdominal distension,belc-hing,nausea and other symptoms scores were gradually decreased,ulcer area decreased,but each time point of the observation group were significantly lower value(P﹤0. 05). The two groups were not found in the digestive tract hemorrhage,the control group adverse reaction rate was 6. 67%,the observation group 3. 33%,group there were no significant difference(P﹥0. 05). Conclusion:sequential oral esomeprazole ESD can effectively promote the healing of wound after operation,better than ome-prazole.