Monitoring and analysis of serum concentration that valproate sodium retard tablets treatment chil-dren and adults epilepsy
HU Yongping
Abstract：Objective:To monitor serum concentration of valproate sodium for children and adults epilepsy,and analyze the data,provide reference for clinical rational drug use. Methods:From January 2013 to December 2015,123 cases with epi-lepsy patients,including 63 cases of adults(adult group),60 children(children group);two groups were rules treated with valproate sodium retard tablets treatment,20 ~ 30 mg·kg - 1 ·d - 1 ,oral administration of 1 to 2 times a day,And use the <br> HPLC method to determination of Serum Concentration. Result:Serum of concentration patients in two groups had significant difference(P < 0. 05). In the of children and adults with epilepsy the curative effect of sodium valproate sustained - release tablets is affirmative. The effective rates were 83. 33% and 90. 48% respectively,But the adult group was better than the chil-dren group(P < 0. 05). Conclusion:Valproate sodium retard tablets in the treatment of epilepsy in children and adults are dif-ferent,the adult group was better than the children group.
Keywords：valproate sodium retard tabletsepilepsychildrenadultserum concentrationmonitoring analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 918-920 )