Child pancreatoblastoma:one case report and review of the literature

Abstract：Objective:To analyze the clinical and pathological features,immunophenotype,diagnosis and differential diag-nosis of Child pancreatoblastoma(PB). Methods:The clinical data of a patient diagnosed with RB was studied. The expression of AE1 / AE3,CD99,S - 100,NSE,Syn,CGA,CD56,NF,Hepatocyte,AFP and PLAP was detected by Full automatic immuno-histochemistry instrument,mucus was detected by AB - PAS method. To analyze the differential diagnosis. Results:The PB rich of epithelial cells. part of the region forming acinar structures,part of the region forming solid sheet,nest like structure,also can visible squamous corpuscles. Immunohistochemical AE1 / AE3 + ,CD99 + ,AFP focal + ,Syn,CGA and CD56 part + . blood AFP Elevated. AB - PAS staining showed myxoid stromal acidic mucus. Conclusion:Although PB is a rare exocrine pancreatic cancer,but it is most common in children with pancreatic tumors. Squamous corpuscles was it's characteristic structure,but its density and distribution in different cases are difference,immunohistochemistry may assist the diagnosis,but no specific,so PB should be differentiated from other pancreatic tumor at diagnosis.