Fingerprint analysisi and chemical pattern recognition for tripterygium wilfordii glycosides tablets
YUN Nairu
Abstract：Objective:To establish the high performance liquid chromatography(HPLC)fingerprint and evaluation system for tripterygium wilfordii glycosides tablets. Methods:Agilent ZORBAX SB - C18 column was used with water and acetonitrile in gradient elution mode. The flow rate was 0. 75 mL/ min and the detective wavelength was 218 nm,and the column tempera-ture was 35 ℃ . The fingerprints for tripterygium wilfordii glycosides tablets from 15 different manufacturers and batches were set up,the similarity assay was carried out by Chinese material medica fingerprint similarity evaluation system(2004A edi-tion),and the peaks were identified by comparing the reference substance. Results:The common mode of HPLC fingerprints for tripterygium wilfordii glycosides tablets were set up. There were 22 common peaks in the fingerprints and three peaks were i-dentified. The whole batches were divided into two parts by cluster analysis and principal component analysis. Conclusion:HPLC fingerprint is an effective method for the quality control of tripterygium wilfordii glycosides tablets with chemical pattern recognition.
Keywords：tripterygium wilfordii glycosides tabletsfingerprintcluster analysisprincipal component analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 598-601 )