Effect of remifentanil on the effective plasma target concentration of propofol in the inhibition of la-ryngeal mask insertion
GUO Yanhui
ZHAO Chongfa
Abstract：Objective:To investigate the effect of different plasma concentrations of remifentanil on the effective concentra-tion of propofol(EC50)in the patients with laryngeal mask insertion. Methods:All 96 patients undergoing elective general an-esthesia for abdominal or limb surgery were randomly divided into four groups of R0,R1,R2 and R3. Target controlled infusion of remifentanil,the target concentrations were 0,1,2,3 ng/ mL,the target concentration was set at the beginning of target con-trolled infusion of propofol,according to the Dixon's sequential method to determine the plasma concentration of propofol. The effects of different target concentrations of remifentanil on the effective plasma target concentrations of propofol were also com-pared. Results:The inhibitory effects of EC50 and 95% CI in R0 group,R1 group,R2 group and R3 group were as follows:3. 38 (2. 52 ~ 4. 54)μg/ mL,3. 11(2. 25 ~ 4. 30)μg/ mL,2. 81(1. 99 ~ 3. 96)μg/ mL,2. 63(1. 89 ~ 3. 66)μg/ mL. Conclu-sion:Target controlled infusion remifentanil injection can strengthen propofol inhibit laryngeal mask insertion reaction effect, target controlled infusion of 0,1,2,3 ng/ mL remifentanil propofol inhibits laryngeal mask insertion reaction in the median ef-fective target plasma concentration of 3. 38 μg/ mL,3. 11 μg/ mL,2. 81 μg/ mL,2. 63 μg/ mL.
Keywords：propofolremifentaniltarget - controlled infusionmedian effective concentration
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 412-414 )