One of the series of studies on the prediction of cancer pain by SELDI-TOF-MS (Capture the the fingerprint marker of cancer pain by SELDI-TOF-MS)
JI Lina
WEI Liang
PEI Yi
Abstract：Objective:To capture the fingerprint marker of advanced malignant neoplasm when pain occurs. Methods:Chose 24 patients with advanced malignant neoplasm confirmed by pathology or cytology,collected peripheral venous blood on an empty stomach,followed up till three months later,they were divided into 2 groups according to the pain occurrence,pain group(9 cases)and painless group(15 cases),by SELDI - TOF - MS(surface - enhanced laser desorption/ ionization time -of - flight mass spectrometry)technique and CM10 proteinchip,these serum proteomic fingerprints were memorized. Results:There were 6 significant different protein fingerprints between painless and pain group,M/ Z values were 2 755,8 678,8 813, 11 361,11 447,11 605. Compared with painless group,M/ Z2755,11 361,11 447,11 605 were up - regulated expressed,and 8 678,8 813 down - regulated expressed. We draw the following results from further analysis:M/ Z 2 755,8 678,8 813 were pres-ent between the two groups,the median value was 6,2,3 in the pain group,and 2,6,10 in the painless group. In addtion,M/ Z 11 361,11 447,11 605 in positive expression of pain,painless group were negative. Conclusion:The protein fingerprints of M/Z2755 high protein expression,M/ Z8 678,8 813 lower expression,M/ Z11 361,11 447,11 605 positive expression can exist as the special fingerprint marker of cancer pain.
Keywords：SELDI - TOF - MScancer painadvanced malignant neoplasm
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 406-409 )