The expression of ezrin and CD44 v6 and clinical significance in breast invasive ductal carcinoma
XU Xin
YAO Dongying
Abstract：Objective:To investigate the expression of Ezrin and CD44v6 and their association with clinical pathological features in breast invasive ductal carcinoma. Methods:Immunohistochemistry was used to detect the expression of Ezrin and CD44v6 in 95 cases of breast invasive ductal carcinoma and 30 cases of normal breast tissue. Results:The positive rates of Ezrin and CD44v6 were 62. 1% and 58. 9% in breast invasive ductal carcinoma respectively,which were much higher than those 23. 3% and 16. 7% in normal breast tissue(P﹤0. 05). The expression of Ezrin and CD44v6 was significantly correlated to lymph node metastasis and TNM stage( P ﹤ 0 . 0 5 ),but it was not related to the age ,tumor size and histolgical degree( P ﹥0. 05). The expression of Ezrin was directly postive correlated to that of CD44v6 in breast invasive ductal carcinoma(P﹥0. 05). Conclusion:Abnormal expression of Ezrin and CD44v6 maybe cooperative effects in development and metastasis of breast inva-sive ductal carcinoma. Combined analysis of these molecules is useful to estimatin of malignancy and metastatic potential of breast cancer.
Keywords：breast neoplasmainvasive ductal carcinomaEzrinCD44v6immunohistochemistry
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 253-256 )