Clinical research of pentazocine and ketorolac tromethamine in preventing the postoperative hyper-algesia induced by remifentanil balanced anesthesia

GAO Qiang; YUAN Dajiang; WANG Lili

Abstract：Objective:To evaluate the efficacy and safety of pentazocine and Ketorolac tromethamine in preventing the hy-peralgesia induced by remifentanil. Methods Sixty patients undergoing posterior lumbar interbody fusion selectivesurgery were randomly assigned to be intravenously injected saline with a equal dose,pentazocine 0. 5mg/Kg,Ketorolac tromethamine 0. 5 mg/Kg,in S group,P group,A group respectively,at 30 minutes before the end of surgery. The patient's respiratory recovery time,recovery time,extubation time,operation time and mean arterial pressure and heart rate after extubation were recorded. verbal rating scales( vRS)were assessed at 5 minutes( T5 min),10 minutes( T10 min),15 minutes( T15 min),30 minutes ( T30 min)respectively after extubation. The number of cases of requiring postoperative analgesia and respiratory depression, irritability,nausea and vomiting was also recored. Results:There was no statistically significant difference between three groups of patients'respiratory recovery time,recovery time,extubation time,operation time and mean arterial pressure and heart rate after extubation(P﹥0. 05). At T5 minutes,the vRS score in S group was higher than that in A group(P﹤0. 05)and the vRS scores comparison between P group and S group,A group respectively is not statistically significant(P﹥0. 05). P group and A group's vRS scores ,indicating no statistical significance( P ﹥0 . 0 5 )when compared ,were both lower than S group's( P ﹤0. 05)at 10 minutes,15 minutes,30 minutes respectively after extubation. There was no statistically significant difference be-tween three groups of patients'analgesia cases and theincidence of irritability,nausea and vomiting,respiratory depression( P﹥0. 05). Conclusion:Pentazocine and Ketorolac tromethamine can effectively prevent the postoperative hyperalgesia induced by remifentanil balanced with propofol anesthesia,without obvious adverse reactions. In addition,the comparison of the function anti-hyperalgesia in both did not maKe any sense in clinic.