The application of HC2 for detection of HR-HPV combined with LCT in screening of cervical le-sions for women in mine

LI Ying; WANG Jintao

Abstract：Objective:To evaluate the value and significance of the second generation hybrid capture detection(HC2)for high risk human papillomavirus( HR-HPV)and thin layer cell inspection( LCT)in screening of cervical lesions women in mine. Methods:The married female employees asked to participate in the screening of cervical lesions in Jincheng Anthracite Mining Group during September 2011 to April 2012 were invited to take part in the study. HR-HPV sample of 6 325 cases was tested by HC2,2 837 cases test sample was tested by LCT. For HC2-HPV DNA testing positive,LCT abnormal cases,col-poscopy biopsy. Results:HR-HPV infection is mainly concentrated in the 30~50 years old. HR-HPV detection specificity in HC2 was 85. 1%,description HC2 high cervical lesions detected when there is no ability to correctly rule out diseases. Ap-plications HC2 and LCT combination of two methods for testing the samples,the specificity and sensitivity of the diagnosis of cervical lesions were significantly improved. 41 cases of patients with cervical inflammation,HPV infection rate was 51. 2%, The HR-HPV infection rates of CINⅠ,CIN Ⅱ,CIN Ⅲ and invasive carcinoma were 77. 8%,92. 3%,100. 0%,100. 0%, description With the increase in the severity of cervical lesions,HPV infection has increased significantly. Conclusion:HC2 for detection of HR-HPV combined with LCT inspection is an efficient and economical cervical lesions screening programs.