The evaluation of clinical efficacy of tolvaptan on treating congestive heart failure patients with hy-ponatremia

FENG Shuai; BAI Chunlin; LOU Xiuping

Abstract：Objective:To evaluate the clinical efficacy of tolvaptan on treating congestive heart failure patients with hy-ponatremia. Methods:Sixty patients who have congestive heart failure with hyponatremia from May 2014 to May 2015 in hospital were enrolled and randomly assigned to experimental group(30 cases,conventional treatment + Tolvaptan)and control group (30 cases,conventional treatment). After 7 days administration of the drug,all the patients were respectively followed every-day,were given at of the serum sodium,and the heart functions,signs and symptoms,volume,body weight and all adverse e-vents were observed. Results:The sodium level was higher in tolvaptan group than in control group,volume increase,body weight decrease,signs and symptoms and heart functions were more significantly outperformed patients in control group. In this experiment,there were drug related adverse events of thirst and frewuent urination in tolvaptan group,however,it could be well tolerated by patients. Conclusion:The effect of tolvaptan was proven by the increasing serum sodium concentration and reducing volume overload that could leads to marked improvement in signs and symptoms,and the related adverse events was low and could be well tolerated by patients. It has a certain clinical value on treating congestive heart failure patients with hyponatremia.