The adverse reaction analysis of statin

ZHANG Hui-fang; HUANG Shu-tian

Abstract：Objective:To analyze the adverse reactions of statins drug to provide a basis for clinical rational drug use. Methods:From January 2010 to January 2013,366 patients in hospital with the adverse drug reactions and reported were choosed and analyzed. The age,sex,happen time and adverse reactions were added up. Results:There are 190 men and 176 women,and the difference was no statistical significant(P ﹥ 0. 05). There are 201 cases beyond 60 years old,and 165 cases under 60 years old,and the difference was no statistical significant(P ﹥ 0. 05). The adverse reactions happened at the least time of 3 days,and the longest time of 1. 5 years. The main adverse reactions included 143 cases of gastmintestinal reactions (39. 1% ),112 cases of muscle toxicity(30. 6% ),78 cases of liver injury(21. 3% ),26 cases of liver and kidney toxicity(7. 1% ),and 7 cases of insomnia(1. 9% ). Simvastatin occurred in 123 cases(33. 6% ),and it was the hightest. Conclusion:St-atins adverse reactions are mainly composed of muscle and liver toxicity,in using process to monitor liver result,CK are needed to void adverse reaction.