The curative effect observation on recombinant human brain natriuretic peptide on the patients with acute decompensated heart failure at different levels of blood BNP

PENG Hui-bing; OUYANG Fan

Abstract：Objective:To evaluate the efficacy of recombinant human brain natriuretic peptide on the patients with acute decompensated heart failure at different levels of blood B - type natriuretic peptide(BNP). Methods:All 160 patients with a-cute decompensated heart failure were assigned to general high group(BNP≤5 000 pg/ mL)or very high group(BNP ﹥ 5 000 pg/ mL)according to their plasma BNP levels. Each group was then subdivided into recombinant human brain natriuretic pep-tide(rhBNP)or other routine subgroups on the basis of intravenous administration with either rountine(routine group)or rh-BNP with rountine therapy(rhBNP group)for 24 h. In the high BNP group,80 patients were randomized to subgroup rhBNP (n = 40)and subgroup rountine therapy(n = 40). In the very high BNP group,80 patients were randomized to subgroup rhB-NP(n = 40)and subgroup other rountine therapy(n = 40). The effects of rountine and rountine therapy on patients in the high and very high BNP groups were compared. Results:In general high group,after treatment,the effective rate of rhBNP group was higher than routine group,urine volume was more than routine group(P ﹤ 0. 05),the situation of color doppler uitrasoud was superior than routine group(P ﹤ 0. 05). In very high group,after treatment,in the high BNP group,rhBNP was more effi-cient than other rountine group,urine volume and the situation of color doppler uitrasoud was no difference. Conclusions:rhBNP was efficient at improving heart function in patients with acute decompensated heart failure when plasma BNP was ≤ 5 0 0 0 pg/ mL. However,rhBNP treatment showed no significant advantages over other rountine therapy when plasma BNP reached ver-y high levels(BNP ﹥ 5 000 pg/ mL).