The clinical characteristics of acute myeloid leukemia patients with CEBPA gene mutations

WU Ji-ying; FAN Jin-ting; ZHAO Fang; MA Jian-hua; FENG Ya-qing

Abstract：Objective:To investigate the clinical characteristics of acute myeloid leukemia(AML)with CEBPA gene muta-tions. Methods:CEBPA gene mutations were detected in 57 patients with newly diagnosed AML by using polymerase chain re-action(PCR)followed by sequence analysis and fragment length analysis. Results:The incidence of mutation was 10. 53% in total AML patients,including 3 with simple mutation and 3 with double mutations. 3 AML - M2 and 2 AML - M4 . The charac-teristics of 51 CEBPA wild type patients vs that of 6 CEBPA mutation patients was as follow,CEBPA mutations were signifi-cantly associated with a lower platelet counts in the peripheral blood,(P ﹤ 0. 05). No statistic difference was found in WBC counts,hemoglobin levels,percentage of blasts in bone marrow and median age(P ﹥ 0. 05). 4 in 6 CEBPA mutation patients with normal karyotype and 9q - ,and while co - existing of FLT3 - ITD mutation was observed in AML - M2 . 5 in 6 CEBPA mutation cases was got complete remission(CR). CR rate was 83. 33% in the CEBPA + patients. It was higher than 71. 74% in the CEBPA - patients,but the result in CEBPA + group was not statistically significant compared with that in CEBPA - group (P ﹥ 0. 05). Conclusion:CEBPA mutation has a certain correlation and laboratory feature. It is necessary to detect CEBPA mu-tation in newly diagnosed AML patients,which might help to molecular classification and treatment.