The detection of the subgroup of the blood T lymphocyte around the patient with B cell lymphoma and the relationship with Ki67

LI Mei-ling

Abstract：Objective:To investigate the role of abnormal T lymphocyte subsets and natural killer cells,and to investigate their relationship of T lymphocyte subsets and Ki67 proliferation index round the patient with B cell lymphoma. Methods:Select the 32 cases of patient with B cell lymphoma(male 18 cases,female 14 cases),aged 36 ~ 62 years old,apply the method of the fluid cell machine(FCM)to detect the T lymph cell and its subsets including total T,Th,Ts and counting of the absolute value of natural killer cells,and calculate the value of Th/ Ts,make a comparison of various data. At the same time,using the immu-nization rate nephelometry to measure the immunoglobulin in the serum. It is divided into low expression group and high ex-pression group according to the positive rate of expression of Ki67,try to understand the relationship between Ki67 and the im-mune function. Results:The Th of the patients with NHL is apparently lower than the normal contrast group(P < 0. 05). The Ts is lower than the normal contrast group( P > 0 . 0 5 ). Total T is apparently lower than the normal contrast group( P < 0 . 0 1 ). Th/ Ts and NK is apparently lower than the normal contrast group(P < 0. 01). Th,total T,Th/ Ts,NK cell in the high expres-sion group of Ki67 are apparently lower than the normal contrast group(P < 0. 05). The Ts of the high expression of Ki67 is ap-parently higher than the normal contrast group(P < 0. 05). Th,total T,Th/ Ts,NK cell in the low expression group of Ki67 are lower than the normal contrast group(P < 0. 05). The Ts of the low expression of Ki67 is higher than the normal contrast group (P > 0. 05). Conclusion:The patient with B cell lymphoma has the cell immunity suppression and disorder,and the basic im-munity is low. The higher the expression of Ki67,the lower the immunity;conversely,the higher the immunity.