Outcomes of intensity modulated radiotherapy for 72 patients with brain metastases from non -small cell lung cancer
LIN Yu-yi
CHEN WAN-quan
ZHANG Wei-jian
HONG Fu-rong
LU Kai-xian
ZOU Xi
Abstract：Objective:Through the observation outcomes with intensity - modulated radiotherapy to explore the efficacy and toxicities of intensity - modulated radiotherapy to treat the brain metastases of non - small cell lung cancer. Methods:A to-tal of 72 non - small cell lung cancer(NSCLC)patients were treated by intensity - modulated radiotherapy(IMRT)with five coplanar beams using simultaneous integrated boost(SIB)technique from May 2008 to November 2012. The prescription dose was 50 ~60 Gy(PTV - G:brain metastases)and 40 Gy by whole - brain irradiation therapy(WBRT)in 20 fractions. Response was evaluated by contrast - enhanced brain MRI or CT one month after the end of radiotherapy. The 95% equi - dosage line in-clude the target area. Results:The complete remission(CR)of imaging was 8. 3% ,partial remission(PR)was 79. 2% ,stable disease(SD)was 6. 9% and progressive disease(PD)was 5. 6% . The effective rate was was 87. 5%(63 / 72). The overall median survival was 13 months. The 1 - year and 2 - years survival rate were 54. 2% and 23. 6% . The main toxicities were nausea and vomiting,brain edema. Conclusion:Intensity - modulated radiotherapy is highly effective and well tolerated in treat-ment of NSCLC with brain metastases. It may be worthy of further clinical investigation and application.
Keywords：lung neoplasmsbrain metastasisradiotherapywhole - brain irradiation therapyintensity - modulated ra-diotherapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 805-808 )