The effect of zoledronic acid on bone around implants and AGEs within marrow space in ovariecto-mized rat
YAM Wen-ting
GAO Ying
JIAO Yan-jun
Lian Bo
Abstract：Objective:To evaluate the effect of zoledronic acid on bone around implants and advanced glycosylation end prodrcts(AGEs)within marrow space in ovriectomized rat. Methods:Three months after bilateral ovariectomy,twenty three -month - old female Sprague - Dawley rats were randomly assigned into two groups for implantation:ovriectomized group and ovriectomized + zoledronic acid group. Three months later,the tibiae were harvested for dual energy X - ray absorptiometry, and examing advanced glycosylation end product(AGEs)by immunohistochemical staining. Results:Bone mineral densityand bone mineral contet:ovriectomized group were lower than ovriectomized + zoledronic acid group,with statistical significance(P< 0. 05). Immunohistochemical staining of AGEs shows that ovriectomized + zoledronic acid group has low positive expression rates than ovriectomized group. Conclusion:Zoledronic acid may inhibit the decrease of bone mass and density aound implants in tibiae and reduce the formation of AGEs.
Keywords：implantzoledronic acidbone mass
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 759-760,762 )