Antibiotic use in children with acute upper respiratory infection:a randomized controlled clinical tri-al observation
WEI Chang-hua
YANG Jian-bin
Abstract：Objective:Compared the differences in clinical efficacy,disease course and disease outcome between single and joint use of antibiotics in treatment of children with acute bacterial upper respiratory infection. Methods:Eighty cases of hospitalized children with acute bacterial upper respiratory infection were divided randomly into two groups,40 cases of treat-ment group were treated with intravenous cloxacillin sodium,40 cases of control group were treated with intravenous penicillin sodium and cefoperazone and sulbactam sodium,all cases were treated with potassium sodium dehydroandroan drographolide succinate for injection,a parallel comparison observation was carried out between two groups. Results:After therapy,there were no significant differences in effective rates beween reatment group(77. 5% )and control group(82. 5% )(P > 0. 05). Both groups were also similar in disease course,disease outcome and adverse reactions. Conclusion:Use of single antibiotic treatment of acute bacterial upper respiratory infections can achieve the intended objective,joint use of antibiotics can not accelerate to improve the symptoms and signs,can not increase the significant effective rates,can not improve the disease outcome,nor short-ened course. Multiple use of antibiotics should be avoided only by personal experiences without clinical evidence.
Keywords：acute upper respiratory infectionchildantibioticreasonable application
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 604-607 )