Diagnostic value of serum microRNA-133 a in older patients with acute non ST-elevation myocar-dial infarction

WANG Jing

Abstract：Objective:AbstractObjective:ThediagnosticvalueofelectrocardiogramandcardiactroponinT(cTnT)eleva-tion in geriatric patients( ﹥65 years old)patients with acute non ST-elevation myocardial infarction( NSTEMI)always pres-ent are limited. And microRNA has key roles in the pathophysiology of acute myocardial infarction. To discusse whether mi-croRNA-133a to be a potential biomarkers of patients with NSTEMI. Methods:Patients with a diagnosis of NSTEMI group( n=28),acute heart failure with non coronary artery etiology group(n=31)and healthy control group(n=33)were enrolled in Shijingshan Hospital of Beijing from July 2011 to January 2014. Beside cTnT,serum microRNA-1,microRNA-21 and mi-croRNA-133a were detected by RT-PCR,and the correction between microRNA and cTnT were analyzed. Results:Serum microRNA-1,microRNA-21 and microRNA-133a showed significant elevation in NSTEMI group compared with healthy control group. And only microRNA-133a showed significant increase in acute heart failure patients compared with healthy control group. In older patients with NSTEMI,microRNA-133a was comparable to cTnT in discrimination NSTEMI compared with healthy control group. And in older patients with moderate elevation of serum cTnT(0. 03~0. 10 ng/mL),microRNA-133a has a higher diagnostic accuracy than acute heart failure( area under ROC curve 0. 85 vs 0. 73,P﹤0. 05). Conclusion:Serum microRNA-133a is significantly elevated in patients with NSTEMI,and it is a sensitive biomarker in diagnostic accura-cy in modest cTnT elevation patients.