Danshen reduced VEGF expression in the lung tissues of model rats with pulmonary fibrosis
YAN Xiao-ning
ZHANG Na
Abstract：Objective:To explore the effects of Danshen on pulmonary fibrosis in the early and middle stages of the dis-ease and their potential mechanism. Methods:Model rats were induced by injecting bleomycin into tracea. 40 Wistar rats were randomly assigned to 4 groups,which were operation control group,model group,prednisone treatment group and danshen treat-ment group. The rats in operation control group were fed with saline everyday,and the rats in Prednsone treatment and danshen treatment group were fed with prednsone and danshen decoction,respectively. After 16 days,the lung tissues were taken out and observed and vascular endothelial growth factor( VEGF ) were measured by enzyme linked immunosorbent assay( ELISA ) method. Results:Compared with Model group,the two treatment groups had significantly improvement in lung operating find-ings. VEGF were significantly lower in the two treatment groups than that in model group(P<0. 01). Conclusion:Danshen could improve pulmonary fibrosis and the one of potential mechanisms was despressing the expression of VEGF in the lung tis-sue.
Keywords：pulmonary fibrosisdanshenvascular endothelial growth factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 438-441 )