Clinical observation on fludarabine combined with cyclophosphamide in chronic lymphocytic leuke-mia
TANG Ru
YANG Tai
WU Yan-ming
Abstract：Objective:To observe the efficacy and safety of fludarabine combined with cyclophosphamide in chronic lym-phocytic leukemia( CLL). Methods:Forty cases of patients diagnosed CLL were randomly divided into treatment group and con-trol group,each of 20 cases. Treatment group was given fludarabine combined with cyclophosphamide. Control group was treated with CHOP regimen. To compare the total efficiency rate and adverse reactions of two groups. Results:The total effective rate of teatment group( 9 0 . 0 0%)was higher than that of control group( 6 0 . 0 0% ),the difference was statistically significant( P <0. 05). There was no statistical difference(P>0. 05)between two groups in rates of gastrointestinal tract reaction,infection and the incidence of bone marrow suppression. Conclusion:Fludarabine combined with cyclophosphamide in CLL has a much better effect and less toxic side effect.
Keywords：fludarabinecyclophosphamidelymphocytic leukemiachronic
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 414-416 )