A clinical observation of recombinant mutant human tumor necrosis factor and cisplatin for malig-nant pleural/peritoneal effusion
LI Xiao-fang
WANG Hai-xiong
PEI Yi
Abstract：Objective:Toinvestigatetheclinicaleffectandadverseofrecombinanthumantumornecrosisfactor(rmhTNF) for malignant pleural/peritoneal effusion. Methods:Fifty-six patients with malignant pleural/peritoneal effusion were enrolled and randomly divided into two groups. Group TNF was infused with rmhTNF,the another one was infused with cisplatin ( DDP). The effective rate,quality of life and adverse reaction were observed. Results:The total effective rate of TNF group was 89. 3%,while it was 64. 3% in DDP group. There was a significant difference between two groups(P<0. 05). The improve-ment rate of KPS in group TNF was 85. 7%,while it was 56. 7% in DDP group. There was a significant difference between two groups(P<0. 05). The adverse reaction rate of TNF group was significantly smaller than DDP group. Conclusion:The rmhTNF is more effective and response quickly with less adverse reaction for treatment of malignant pleural/peritoneal effusion.
Keywords：malignant pleural/peritoneal effusionrecombinant human tumor necrosis factorcisplatin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 406-408 )