The efficacy observation on levofloxacin combine with cefuroxime for chronic obstructive pulmonary disease exacerbations

HAN Jia-yu

Abstract：Objective:To research and analysis the clinical efficacy of levofloxacin combine with cefuroxime for chronic obstructive pulmonary disease exacerbations. Methods:Nighty cases with chronic obstructive pulmonary disease exacerbations from January 2011 to December 2013 were randomly divided into observation group and control grou,45 patients in each group,the control group received levofloxacin treatment,observation group received levofloxacin and cefuroxime combination therapy,the lung function before and after treatment,blood gas analysis laboratory parameters and the clinical efficacy after treatment were observed and compared. Results:The total effective rate in observation group was significantly better than the control group,the data were statistically significant differences(P < 0. 05). The forced respiratory volume(FEV1 )within 1 s af-ter treatment,FEV1 value within the estimated ratio(FEV1% ),FEV1 and forced vital capacity(FVE)ratio(FEV1 / FVE),arte-rial oxygen tension(PaO2 ),arterial carbon dioxide partial pressure(PaCO2 )and white blood cell count(WBC)in two group have received some improvement after treatment,the data has statistically significant before and after treatment(P < 0. 05);and the improvement of the observation group was significantly better than the control group ,it has statistically significant( P <0. 05). Conclusion:The combination of levofloxacin and cefuroxime in the treatment of chronic obstructive pulmonary disease exacerbations,significant clinical effect,can significantly improve patients' lung function,blood gas and other laboratory param-eters.